In 1990, almost 500 years after the creation of The Creation Of Adam, Frank Lynn Meshberger, MD published a paper establishing the following:
The Creation of Adam (1508-1512) on the ceiling of the Sistine Chapel has long been recognized as one of the world’s great art treasures. In 1990 Frank Lynn Meshberger, M.D. described what millions had overlooked for centuries — an anatomically accurate image of the human brain was portrayed behind God. On close examination, borders in the painting correlate with sulci in the inner and outer surface of the brain, the brain stem, the basilar artery, the pituitary gland and the optic chiasm. God’s hand does not touch Adam, yet Adam is already alive as if the spark of life is being transmitted across a synaptic cleft. Below the right arm of God is a sad angel in an area of the brain that is sometimes activated on PET scans when someone experiences a sad thought. God is superimposed over the limbic system, the emotional center of the brain and possibly the anatomical counterpart of the human soul. God’s right arm extends to the prefrontal cortex, the most creative and most uniquely human region of the brain.
https://anatomiaitaliana.com/wp-content/uploads/2013/05/MichelangeloCreationBrain.pdf
Article published in JAMA Journal of the American Medical Association on Nov. 1990 https://www.researchgate.net/publication/20949787_An_Interpretation_of_Michelangelo’s_Creation_of_Adam_Based_on_Neuroanatomy